Endocrine Abstracts

Introduction: The presence of anti-thyroglobulin antibodies (ATG) can induce falsely lower thyroglobulin (Tg) values. The methods characteristics used for ATG measurement vary according to the equipment/reagent used. ATG at our centre is measured by Unicap.Objective: To assess if patients with negative ATG by Unicap® have different results with other equipment.Methods: A cross-sectional retrospective study was condu...

Thyroid carcinoma is the most common endocrine malignancy and represents ~1% of all types of human cancer.Objective: As the molecular pathogenesis of thyroid cancer still remains to be clarified, the goal of our study was to find new molecular markers that could improve the diagnostics, follow-up protocols, treatment outcome, prognosis and the quality of life of differentiated thyroid cancer patients.Subjects and methods: Matched t...

Introduction: Gestational diabetes (GD) is associated with a significantly higher risk of perinatal complications. It has been suggested that third-trimester (3thT) foetal abdominal circumference (fAC) determination is an important predictor of macrossomia and large for gestational age (LGA).Aims: The purpose of this study was to evaluate the association between the 3thT fAC percentile with birthweight (BW) and adverse neonatal outc...

Introduction: The need to fast for the determination of lipid profile has been discussed in the past years, for several reasons – i) most of the day time is spent in a postprandial state; ii) the lipid concentrations seem to be only slightly affected by a normal meal; both fasting and postprandial can predict cardiovascular risk.Aim: Determine the influence of normal food intake on the lipid profile of diabetic patients.Method...

Introduction: Monosomy 18q represents a partial deletion of the long arm of chromosome 18, with an estimated prevalence of 1:100 000. This syndrome is characterized by a highly variable phenotype. The symptoms and their severity depend on which part of the chromosome is missing. Most common manifestations are hypotonia, developmental delay, short stature, growth hormone deficiency, hearing loss and external ear anomalies, intellectual disability, palatal defects, dysmorphic fa...

Introduction: Current guidelines recommend a single prolactin sampling for the diagnosis of hyperprolactinaemia. Nonetheless, in some patients, prolactin levels may normalize in a subsequent sampling or if prolactin is collected through a venous catheter some time after puncture. We aimed to assess the percentage of patients in which prolactin remained elevated in repeated sampling and to determine the best prolactin cutoff associated with persistent hyperprolactinaemia.<p...

Hyponatremia is a common disorder, especially among the elderly, and an important morbidity and mortality cause. Empty sella syndrome, on the other hand, is a rare entity, more common in women between their fourth and sixth decade of life, and endocrine dysfunction has been reported in 10–60% of the cases. A 68-year-old man, with a past medical history of essential hypertension and glaucoma, presented at the emergency room due to malaise, asthenia, somnolence and anorexi...

Introduction: Our group has a bank of human primary thyroid cultures (BANTTIC) obtained from patients. All are individual cultures specifically genotyped and phenotyped. We believe of great interest the search for biomarkers in these cultures using differential proteomic analysis.We have applied differential proteomics using 2D-PAGE coupled to MALDI-TOF-TOF-MS. We have compared benign pathologies (normal thyroid and Pendred’s syndrome) and different...

Male transgenic (TG) mice overexpressing both the hCGα- and hCGβ- subunits present elevated levels of circulating hCG, Leydig cell hyperplasia/hypertrophy, elevated androgen levels and infertility (Rulli et al. 2003). In addition, serum FSH is significantly reduced in prepuberal and adult TG males compared with wild-types (WT), and does not change after treatment with the antiandrogen flutamide. The aim of this study was to evaluate the regulation of the hypot...

Introduction: Islet hyperplasia and nesidioblastosis are described in the non neoplastic pancreas of patients with gastrinoma. It is not definately established whether hypergastrinemia can influence these changes. Moreover, rarely insulinoma and gastrinoma occur in the same patient but cases of single tumours cosecreting both insulin and gastrin have been described. Otherwise, the syndrome of hyperinsulinemic hypoglycaemia with nesidioblastosis after Roux-en-Y gastric bypass h...